Current and future perspectives of single-cell multi-omics technologies in cardiovascular research

Wilson Lek Wen Tan, Wei Qiang Seow, Angela Zhang, Siyeon Rhee, Wing H. Wong, William J. Greenleaf & Joseph C. Wu

Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic and epigenetic heterogeneity in cardiac disease and development. We then introduce the key concepts in single-cell multi-omics modalities that apply to cardiovascular research. Lastly, we discuss some of the trending concepts in single-cell technology that are expected to propel cardiovascular research to the next phase of single-cell research.

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