Induced pluripotent stem cell technology: a decade of progress.

Yanhong Shi, Haruhisa Inoue, Joseph C Wu, Shinya Yamanaka

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline, and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and three-dimensional organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine. In this overview, we will discuss the progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, in light of the remaining challenges and the emerging opportunities in the field.

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