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GSB-L868

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Our Cell Products

We offer a portfolio of high-quality, human iPSC-derived cell types. Each is validated for identity, functionality, and consistency—ideal for disease modeling, drug screening, electrophysiology, immunology, and tissue engineering.

Ventricular Cardiomyocytes

Ventricular cms for website_0014_trans
image (1)

Human iPSC-derived Ventricular Cardiomyocytes

These cells are produced via standardized processes to possess a robust, ventricular-like phenotype. Their moderate spontaneous beat rate and well-defined action potentials make them particularly suitable for electrophysiological assays and compound profiling.

Benefits

  • High purity ventricular phenotype
  • Strong functional resemblance to human heart ventricular cardiomyocytes
  • Reliable responses in electrophysiology, safety, and pharmacology assays

Product Specifications

Feature

Detail

Identity Markers

≥ 85% cardiac Troponin T (cTnT+) by flow cytometry at Day 3; expression of ventricular marker MLC2v; sarcomeric markers (e.g. TNNT2), downregulation of progenitor/undifferentiated iPSC genes.

Quantities

≥ 1 × 10⁶ and ≥ 4 × 10⁶ viable cells

Quality Control

Cell count, viability, identity (FACS), functionality (e.g. Voltage Sensitive Dyes/Calcium Sensitive Probe: response to isoproterenol, dofetilide, nifedipine), mycoplasma testing

Format

Cryopreserved

Donor & Reprogramming

Specified donor (female/male; healthy/diseased as applicable); Sendai Virus reprogramming

Shipping / Storage

Dry shipper at -180°C to -135°C; store in vapor phase of liquid nitrogen

Supplied with

Cardiomyocyte culture medium; user-guide/instructions for thawing / seeding / maintenance / maturation

Figure 1. Electrophysiological validation. Greenstone Biosciences ventricular cardiomyocytes baseline action potentials and response to hERG Channel blockade ( red symbols, 30nM, E4031).

Technical Data

  • Clear structural sarcomere alignment, α-actinin / myosin heavy chain staining
  • Action-potential recordings show fast upstroke, distinct plateau phase typical of human ventricular myocytes
  • Ventricular CM APD>>Atrial CM APD
  • Response to adrenergic stimulation (e.g. isoproterenol) as well as to ion channel blockers (e.g. L-type Ca²⁺ channel blockers, hERG blockers, Na channel blockers)

Atrial Cardiomyocytes

Human iPSC-derived Atrial Cardiomyocytes

Engineered to express atrial-specific electrophysiological and molecular signatures. They beat at spontaneous rates and have action potential morphologies characteristic of atrial cardiomyocytes—useful for atrial arrhythmia modeling and for testing drugs targeting atrial-selective pathways.

Benefits

  • Atrial gene marker expression (e.g. KCNA5, NPPA, GIRK (IKAch))
  • Electrophysiological profiles suited to atrial physiology studies
  • Strong for comparative studies vs ventricular types; arrhythmia / AFib models

Product Specifications

Figure 2. Atrial hiPSC-CM electrophysiological validation. Atrial hiPSC-CM APD90 << Ventricular hiPSC-CM APD90. Greenstone atrial hiPSC-CMs respond to Dofetilide (100nM) as expected with significant APD prolongation.

  • Identity: high purity atrial marker expression; minimal ventricular contamination
  • Sizes, QC, format, shipping as per ventricular line
  • Functionality: response to atrial-relevant ion channel modulators; beat rate and action potentials matching atrial reference data
  • Response to adrenergic stimulation (e.g. isoproterenol) as well as to ion channel blockers (e.g. L-type Ca²⁺ channel blockers, hERG blockers, Na channel blockers)
  • Atrial CM APD<<Ventricular CM APD

Fibroblasts

Human iPSC-derived Fibroblasts

Widely used to study ECM remodeling, fibrosis, cell signaling, and wound repair. These fibroblasts show robust secretion of matrix proteins and support for co-culture and 3D tissue systems.

Benefits

  • High expression of fibroblast markers (e.g. Vimentin, FSP1, DDR2, PDGFR-α)
  • Strong ECM production, contractility in gel contraction assays
  • Compatible with co-cultures, organoids, 3D matrices

Product Specifications

Figure 3. Representative immunofluorescence images showing stage-specific cells express pluripotency genes (iPSC; NANOG and SSEA4), pass through epicardial cell lineage (EPC; ZO1 and WT1) and cardiac fibroblast (CF) genes (GATA4 and DDR2) during the differentiation process. DAPI=nucleus stain. Scale bars, 100µm. From Zhang et al, Methods Mol Biol. 2022;2454:109–115. doi: 10.1007/7651_2020_300

  • Identity via marker panels; QC includes viability, mycoplasma, functional assays (e.g. ECM deposition)
  • Supplied cryopreserved; sizes scaled to research or higher throughput needs
  • Proper donor background info available

Smooth Muscle Cells

Human iPSC-derived Vascular Smooth Muscle Cells

Designed for vascular biology, these smooth muscle cells (SMCs) respond to vasoactive agents and display marker expression and phenotype switching characteristic of vascular SMCs.

Benefits

  • Expression of key SMC markers (ACTA2, MYH11, CNN1, TAGLN)
  • Functional contractile behavior; responsiveness to vasoconstrictors / dilators
  • Useful for disease modeling (hypertension, vascular remodeling), tissue engineering, screening

Product Specifications

  • Identity & purity assessed; QC includes contractility assays, viability, donor background
  • Cryopreserved, multiple scale sizes; shipping & storage under liquid nitrogen vapor phase

Macrophages

Human iPSC-derived Macrophages

Tailored for immunology, inflammation, infectious disease, and cell-cell interaction studies. These macrophages can be polarized (M1 / M2), secrete cytokines, and perform phagocytosis reliably.

Benefits

  • High expression of macrophage markers (CD14, CD68, CD11b)
  • Functional assays: phagocytosis, cytokine profile upon stimulation (e.g. LPS, IFN‐γ)
  • Good for modeling immune response, inflammatory disease, host-pathogen interaction

Product Specifications

  • Identity/purity QC, functional validation (phagocytosis, polarization, cytokine secretion)
  • Cryopreserved format; supply with macrophage media; standard donor info; mycoplasma free

Endothelial Cells

Human iPSC-derived Endothelial Cells

Human iPSC-derived endothelial cells provide a reliable and renewable source for vascular biology research. These cells exhibit robust endothelial identity, form functional vascular networks, and respond to angiogenic and inflammatory signals, making them a powerful platform for disease modeling, drug discovery, and regenerative medicine.

Benefits

  • Expression of key endothelial markers (CD31/PECAM1, VE-Cadherin, vWF, eNOS)
  • Responsive to shear stress, cytokines, and pro-angiogenic/anti-angiogenic factors
  • Suitable for vascular disease modeling (atherosclerosis, angiogenesis, thrombosis), tissue engineering, and compound screening

Product Specifications

Feature

Detail

Identity Markers

Sucrase isomaltase (enterocytes), (MUC2 (goblet cells), LGR5 (stem cells), Lyz (Paneth cells)

Quantities

≥ 500 organoids/ crypt like structures per vial

Quality Control

Markers characterization , mycoplasma testing

Format

Cryopreserved

Donor & Reprogramming

Healthy/ diseased  donor-derived iPSCs; Sendai virus reprogramming

Supplied with

Handling guide and instructions for differentiation and culture
  • Identity & purity assessed; QC includes tube formation, nitric oxide production, and viability assays
  • Cryopreserved, multiple scale sizes available; shipping & storage under liquid nitrogen vapor phase

Epithelial Cells

Human iPSC-derived Intestinal Epithelial Cells

These organoids mimic the structure and cellular diversity of human intestinal epithelium.IPSC-derived intestinal products show a crypt-like structure, which is the common feature of intestinal epithelium. They contain enterocytes, goblet cells, Paneth cells, and enteroendocrine cells. They are valuable tools for studying gut barrier function, host-microbiome interactions, screening drugs, assessing pharmacokinetic profiles of potential medications, and testing the toxicology of possible interventions.

Benefits

  • Physiological 3D intestinal architecture
  • Contains absorptive and secretory cells
  • Suitable New Approach Method (NAM) for gut disease modeling
  • Develops a high-throughput platform for drug screening and assessing the toxicology of potential drugs.

Product Specifications

Feature

Detail

Identity Markers

Sucrase isomaltase (enterocytes), (MUC2 (goblet cells), LGR5 (stem cells), Lyz (Paneth cells)

Quantities

≥ 500 organoids/ crypt like structures per vial

Quality Control

Markers characterization , mycoplasma testing

Format

Cryopreserved

Donor & Reprogramming

Healthy/ diseased  donor-derived iPSCs; Sendai virus reprogramming

Supplied with

Handling guide and instructions for differentiation and culture

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