Benefits
- High purity ventricular phenotype
- Strong functional resemblance to human heart ventricular cardiomyocytes
- Reliable responses in electrophysiology, safety, and pharmacology assays
Product Specifications
|
Feature |
Detail |
|---|---|
|
Identity Markers |
≥ 85% cardiac Troponin T (cTnT+) by flow cytometry at Day 3; expression of ventricular marker MLC2v; sarcomeric markers (e.g. TNNT2), downregulation of progenitor/undifferentiated iPSC genes. |
|
Quantities |
≥ 2 X 10⁶ and ≥ 5 X 10⁶ viable cells |
|
Quality Control |
Cell count, viability, identity (FACS), functionality (e.g. Voltage Sensitive Dyes/Calcium Sensitive Probe: response to isoproterenol, dofetilide, nifedipine), mycoplasma testing |
|
Format |
Cryopreserved, ready-to-thaw vials |
|
Donor & Reprogramming |
Specified donor (female/male, healthy/disease as applicable); Sendai Virus reprogramming |
|
Shipping / Storage |
Shipped in dry ice shippers at -20°C to -80°C |
|
Supplied with |
User guide with instruction for thawing, seeding, maintenance and maturation |
Figure 1. Electrophysiological validation. Greenstone Biosciences ventricular cardiomyocytes baseline action potentials and response to hERG Channel blockade ( red symbols, 30nM, E4031).
Technical Data
- Clear structural sarcomere alignment, α-actinin / myosin heavy chain staining
- Action-potential recordings show fast upstroke, distinct plateau phase typical of human ventricular myocytes
- Ventricular CM APD>>Atrial CM APD
- Response to adrenergic stimulation (e.g. isoproterenol) as well as to ion channel blockers (e.g. L-type Ca²⁺ channel blockers, hERG blockers, Na channel blockers)
Explore Ventricular Cardiomyocytes
Discover our high-purity, iPSC-derived ventricular cardiomyocytes designed for cardiac safety, electrophysiology, and drug discovery research. Check out the product details to see how these cells can accelerate your studies.